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港人壓力大,抑鬱症越趨普遍。若確診抑鬱症,患者有需要服用多種抗抑鬱藥物,必要時或需加大劑量。當服用兩種或以上一定劑量的抗抑鬱藥物,並持續一段時間,治療效果卻不甚理想時,醫學上便稱為「難治型抑鬱症」。統計顯示,有關病人佔抑鬱症患者多達三分一,絕對不容忽視。

現時醫學界積極發開發針對谷氨酸系統 (glutamate)的新抗抑鬱藥物。透過雙管齊下的藥物治療方案,對比過去30年的主要透過調節大腦中單胺系統(monoamine)抗抑鬱藥物,包括血清素多巴胺去甲腎上腺素的信號傳遞療法,臨床所見平均大約服用二至三星期才見效,而且並非對所有抑鬱症患者都能奏效之下,患者使用針對谷氨酸系統 (glutamate)的新抗抑鬱藥物有望在更短時間內減輕抑鬱情緒,得到緩解。

抑鬱症有多種治療方案,各有其成效、副作用及限制,患者應與自己的主診醫生商討,選用最合適的治療方案。若出現抑鬱症症狀便應儘早求助及求醫,及早治療處理症狀。

若想了解更多有關針對谷氨酸系統 (glutamate)的新療法,可按此參閱詳情,或直接聯絡查詢。

Urinary Frequency

Dear Dr. Chan,
I felt 急尿 frequently but can’t instantly excrete (need to wait around 5 mins and only excreted a little bit) and a bit scared. Is this normal? I took an antidepressant and anxiolytic as normal practice but the very sleepy benzodiazepine. My menstruation should be starting around this Saturday as well.
This is the first time I felt scared at night after taking the medicine and is this a normal reaction or side effects of the medicine? Thanks very much for your help! 🙏🏻
Best Regards,
xxx
Reply from Dr. Chan Man Lui, Doris

Dear xxx,
Urinary frequency ( 急尿) is not normal. Having urinary hesitancy is not normal either. You need to find out the cause for sure.  The commonest cause for urinary urgency is urinary tract infection. Usually it comes along with haematuria (i.e. blood in the urine) and dysuria (pain while passing urine).
As for urinary hesitancy, it is uncommon in female as the urethra is short in female. The commonest cause is benign hypertrophy of prostate (BPH), which only happens in male counterparts.
As regard to whether the medications causing you this problem, it would be difficult to make a comment on this issue, because different patient has different reactions to medications. Therefore, it needs to be assessed in person to explore this cause.
Therefore you can see a general practitioner for further assessment first. If after assessment and yet you could not find any problem, then it may be due to mood problem, like anxiety or in rare case, related to the side effect of your current medications. By then, you can see me for further management.
BR
Dr. Chan

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