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港人壓力大,抑鬱症越趨普遍。若確診抑鬱症,患者有需要服用多種抗抑鬱藥物,必要時或需加大劑量。當服用兩種或以上一定劑量的抗抑鬱藥物,並持續一段時間,治療效果卻不甚理想時,醫學上便稱為「難治型抑鬱症」。統計顯示,有關病人佔抑鬱症患者多達三分一,絕對不容忽視。

現時醫學界積極發開發針對谷氨酸系統 (glutamate)的新抗抑鬱藥物。透過雙管齊下的藥物治療方案,對比過去30年的主要透過調節大腦中單胺系統(monoamine)抗抑鬱藥物,包括血清素多巴胺去甲腎上腺素的信號傳遞療法,臨床所見平均大約服用二至三星期才見效,而且並非對所有抑鬱症患者都能奏效之下,患者使用針對谷氨酸系統 (glutamate)的新抗抑鬱藥物有望在更短時間內減輕抑鬱情緒,得到緩解。

抑鬱症有多種治療方案,各有其成效、副作用及限制,患者應與自己的主診醫生商討,選用最合適的治療方案。若出現抑鬱症症狀便應儘早求助及求醫,及早治療處理症狀。

若想了解更多有關針對谷氨酸系統 (glutamate)的新療法,可按此參閱詳情,或直接聯絡查詢。

Benzodiazepines dependence

My name is xxx and I have been diagnosed with panic disorder 17 years ago. I am on an antidepressant, an antipsychotic drug, an unknown benzodiazepines at 15 mg (5 mg x 3 a day) and another anxiolytics. I am seeing another psychiatrist now and he said I am Benzodiazepines dependency. I would want to know if is the right time for me to taper off my benzodiazepines, are the medications I am taking the right one for me? I still feel panicky all the time as the benzodiazepines doesn’t work well any more. I am in a very depressive mood now and I am seeking for help eagerly. Thank you and I am looking forward in hearing from you.

Reply from psychiatrist, Dr. Chan Man Lui, Doris

Dear xxx,

Although panic disorder seems to be a simple condition, sometimes it can be quite debilitating. Using benzodiazepine group of drugs usually is a temporary measure to relieve the symptoms before other medications comes to effect. or as an adjunctive treatment. If the benzodiazepine group of drugs have been taken for a long time, sometime it can cause dependence. However, since I have not seen you in person, I cannot judge whether you have got benzo dependence or whether it is right timing to tail off the drug at this moment.

You can discuss with your psychiatrist about the issue.  Of course, you are more than welcome to come to see me for a second opinion.

Please kindly contact my assistant Miss Wong @ 23108918 for further information.

BR

Psychiatrist, Dr Chan Man Lui, Doris

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